eISSN : 2713-8631
수면정신생리 (5권2호 185-193)
Nonlinear Dynamic Analysis of EEG in Patients with Positive and Negative Schizophrenia
양성 및 음성 정신분열증 환자 뇌파의 비선형 역동 분석
Chae, Jeong-Ho;Pak, E-Jin;Kim, Dai-Jin;Jeong, Jae-Seung;Kim, Soo-Yong;Kim, Kwang-Soo;
Department of Psychiatry, College of Medicine, The Catholic University of Korea, Catholic Brain Neuroscience Center;Department of Psychiatry, College of Medicine, The Catholic University of Korea, Catholic Brain Neuroscience Center;Department of Psychiatry, College of Medicine, The Catholic University of Korea, Catholic Brain Neuroscience Center;Department of Physics, Korea Advanced Institute of Science and Technology;Department of Physics, Korea Advanced Institute of Science and Technology;Department of Psychiatry, College of Medicine, The Catholic University of Korea, Catholic Brain Neuroscience Center;
Objectives : The hypothesis that the brain is a nonlinear dynamical system exhibiting deterministic chaos has offered new perspectives to the investigation of information processing in the brain of schizophrenic patients. It seemed worthwhile to estimate nonlinear measures of the electroencephalogram (EEG) in positive and negative schizophrenics, because nonlinear measures might serve as indicators of the specific brain function in schizophrenia according to specific psychopathologies. Method : Previous studies which estimated the chaoticity in the brain of schizophrenia with nonlinear methods recorded the EEGs at limited electrodes, so we tried to record EEGs from 16 channels for nonlinear analysis in 8 positive and 9 negative schizophrenics and 8 healthy control subjects. We employed a new method to calculate the nonlinear invariant measures. For limited noisy data, this algorithm was strikingly faster and more accurate than previous ones. Results : Our results showed that the patients with negative schizophrenia had lower the first positive Lyapunov exponents (
Schizophrenia;Chaos;EEG;Nonlinear dynamics;Lyapunov exponent;